I don't have an FX, but I have built my own double regulated gun . . . . here is why it is done.
All regulators deliver a slightly non-linear response; their average output is not exactly the same under the impact of two variable conditions. The first is variation in the air used per shot or cycle, and we tend not to vary that one much (we tune to a power level and stick with it for consistency of shots). The second is variation in the pressure ahead of the regulator, and that can vary a lot - especially in guns with bottles meant for high fills (like 250 bar) with much lower regulated set points (typically down around 100 - 180 bar range or so). While this variation is not huge, it is real and can show up in projectile speed values.
Enter the two regulator approach: use of an additional regulator to stabilize the input to the regulator that controls the air in the plenum for the firing charge - doing this will "tighten up" the variation on the output of that regulator.
So what does that mean with respect to the OP question? Simple: if you want the best, most stable performance, refill before the reservoir pressure falls below the setpoint of the first (or feeder) regulator. But if you wait until later, when the pressure gets closer to the second (or firing plenum feeder) regulator, everything will still function well, but maybe with a little higher variation in projectile speed (and we are talking little here - probably less than 10 fps or so). The first regulator is just acting as a restriction in the path, but is having no impact on the air pressure the second regulator sees as the pressure is now below the set point of that first regulator.
Hope that helps!