Same here as I've used a semi-auto rimfire for pest hunting since childhood (10/22). Eyes are not what they used to be so for close quarter shooting I use a red dot reflex. If noise is an issue, the 250 barks a bit even in .22. If you add a moderator it certainly is not as compact in the field. I find a great compromise is to use the STO insert inside the 250 factory shroud.
If you need more ballistics at over 35 yards you have to go to the 350 barrel. My eyes require a scope at anything over 35 yards anyway so compactness is less than ideal. Again, if noise is an issue the STO insert in the factory 350 shroud will keep noise down and length to a minimum.
The STO inserts are better than stock but not as effective as aftermarket options. Noise is an issue for me and I've found the best setup for close quarters is to use the 250 barrel with the stock 350 shroud combined with the long STO insert.
Again, one of the things I like about the L2 is the ease to use it for many hunting applications. I have up to 600mm barrel with .30 and it has decent knock down at 100+ yards. I don't own the 9mm but I'm sure it would be a step up if needed.
I always use a 350 tank with my .30 setups. It is usually on the gun because it is a hassle to change. One thing to note is if you have an aftermarket hand guard you cannot fold the stock with the big tanks and lock it in place without an extended lock pin. They lock fine with the factory shrouds.
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