I think if you have the inserts and find the noise difference a lot quieter than stock then it probably won't get much better than that to be honest, especially with a 250 barrel. I haven't tried or bought more stacks for my Mod50, which may possibly reduce noise further, but I fear it wouldn't have the near silent effect you're probably after. I think it's because of the nature of the gun being quite open at the back unlike breech fed mechanisms more than anything. I would guess the Mod50 to be slightly quieter than the stock with inserts but probably not by much, especially if you're running 130 plus on your regulator with a 250 barrel. I have run a 600mm barrel in .22 with a pretty standard 1/2 inch UNF moderator and found it actually a lot quieter than the M50 on my 250mm barrel, bur still nothing near as quiet with that same moderator on one of my breech load guns, which would be silent down to a barely audible, "click".
As for the regs. As we're limited to 12ft pounds here in the UK our set ups are generally about shot count with accuracy and regs generally set at 70bar or less for the Leshiy 2. So that's 70bar reg holding off 250 to 300bar fill. I've taken to tinkering a little, mainly because you can with this rifle and was intrigued by a the new FX set ups with double regs, and seeing as the leshiy plenums can basically screw into one another thought I'd give it a try and see if it would take a little pressure off the 70 bar reg by reducing it to 100 bar first with this set up. It really does seem to work. I'm getting really consistent chrono readings and really tight groups.
I have tinkered quite a bit since I first received this gun. I was quite disappointed in it's performance at first. I got among the early batch shipped out in Europe so they were basically a standard configuration with regs set at 130bar and the ft pounds determined by the size of the puck when it arrived. So you can imagine I was getting probably 3 magazines worth per fill, which is awful for 12ft pounds! So much air was being dumped! The accuracy was also all over the place. Anyway, since then I've adjusted the reg down, adjusted jet sizes, and concluded that 1 jet with a screw was best, and reduced plenum sizes and feel I've found a really excellent combination for my set up.