After trying a few combination of tunes to shoot a wide range of pellets and slugs from my bone stock .22 M4 (CF sleeve is the only "mod" so far), I have settled on this "broad band" tune to cover everything from 14.3gr CPHP pellet all the way up to 25gr slugs or pellets.
Reg - 110 bar
Valve - line 4
Minimum Micro/Macro - 2.2/1
Maximum Micro/Macro - 3.7/16
I could switch back and forth between a variety of pellets and slugs on the fly with the Macro wheel alone now, the Micro was being set at the range of around 2.2 to 3.7 in conjunction with 110 bar reg for the broad spectrum coverage, and I could always dial down the valve on as needed basis.
14.3gr CPHP - Macro at 1 = 900~910fps
15.9gr Hades/FX Atomic - Macro at 4 = 930~940fps
18gr JSB - Macro 6 = 900~910fps
20gr NSA slug - Macro 12 = 960~970fps
22gr FX Hybrid - Macro 15 = 970~980fps
25gr AEA pellet or NSA/Knockout slugs - Macro 16 = 910~920fps
50ft-lb is as far as I would feel comfortable pushing the M4 as my "daily driver". I have no need and no where to utilize the upper power band potential in 70~80ft-lb territory. Not at all being tempted by the big powar being advertised and glamorize by youtubers, i tuned my M4 to suit my own need and usage, don't have any desire or the need to sling super heavy 40gr slugs either.
For backyard pesting, either the 15.9gr Hades/Atomic or the 22gr Hybrid have way more than enough oomph, for backyard target shooting i use the dirt cheap 14.3gr CPHP, won't feel guilty to plow through 250 to 500 rounds in one day either. Still waiting for Griffin LDC slugs that I've ordered in 17, 19, 21, and 23gr in both 217 and 218, this current tune will certainly cover them.