This only generally if you are one that shoots both pellets and slugs. each has a generally preferable tune to achieve best grouping. But this question can apply to different power setting for pellets as well. So, would you be content to set a flexible power gun for all needs, or do you acquire a gun for the purpose? I guess money would dictate this. For example, I have a vet 2 in 22 that can be adjusted fairly quick between 18-44 foot pounds energy. but I would prefer to set the vet high and get , say , a BRK atomic or similar for the low power applications. I maintain money is the overiding factor in the decision, but if not, what would you chose?