Yes, I put a Huma bottle reg on my .22 RW HP for about 3 or 4 months, and shot with it that way at the TexTreme Benchrest in October 2020. It MIGHT be OK for .177, but for .22 HP you'll also need an additional plenum to go between the reg and the breech block. Altaros sells one. Even so, it will reduce the maximum power that you can achieve compared to a stock RW HP. You'll need to set it at 185 to 190 bar, ,which is at the upper limit of what the Huma can be adjusted to. After the TexTreme I removed it and returned my RW HP to the stock configuration since there was really no benefit to using it and some detriment... You would think that ES would improve, and it did, but not enough to make a difference, from perhaps 12-13 FPS to 9-10 FPS.
I have installed a Huma in the tube of my .177 standard Pulsar FT gun, and in that situation it did make a difference in consistency. I have it set to 145 to 150 bar, and it can shoot a 90 shot string with an ES of approx 6 to 7 FPS for the entire string with 13.4 RD Monsters at 815 FPS...
Both guns have HeliBoards.