All you have to do is look up to see which is more dense, (breathable) air or helium.
Air is more dense. Therefore, air has more power behind any given psi value. Less, squish ! Sorta (!) like air vs water. Air compresses, water doesn't !
Air compresses, helium compresses...more.
Also, helium molecules are smaller than (breathable) air. So it seems that any gun, with o-ring problems would become a problem sooner.
! - Air expands with heat, more than helium does, so the helium will hold its pressure, more stable going from hot to cold, visa-ve .
2 - The use of helium will be a "cleaner" medium for your gun. No moisture (water) inclusion while filling your gun, therefore...no internal rust.
3 - The last thing...compressed air is cheaper than compressed helium, and easier to get.
A simple lookup in the internet if you don't know it.
Mike