Shooting skunks with 30 cal will cause them to spray. A 22 in the motor usually results in taking a few steps, tettering over and no spray.
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I have a Notos in .22 and a Vevor compressor. I was concerned that .22 would not be enough for a humane kill.If you go with a .22, all you really need is a NOTOS and a Hand Pump. Very budget friendly, noise friendly, and with an inexpensive scope would more than get the job done. Perfect is the enemy of good enough.