I started with a Benjamin Marauder pistol (Prod) and a hand pump. It only stores 60 cc of air and can only be filled to 3000 psi so it is a great gun for hand pumping. I found the stock tune a little low on power and turned it up some and it's taken 17 squirrels for me so far. If I hadn't added an Avenger next, I might still be hand pumping. For small guns with modest pressure needs I found it works fine. Others are more tolerant of hand pumping and do it for much larger guns. Another variable in my mind is target shooting versus hunting. Hunting requires relatively few shots so hand pumping is not bad. Target shooting can involve many more shots where hand pumping gets old.
My other reason to comment again on this is my recomendation of a 22 caliber. I think it is the best all around choice but I've been enjoying my P35-177 and it's taken 15 squirrels for me so far. Pellets are even cheaper than 22. The regulator came set to 125 bar in my 177 versus 135 or more for the 22 and 25. It also uses less air per shot. I can get close to 100 shots per fill with the 177 whereas the others are closer to half that. So if I was hand pumping I would seriously consider a 177. It has adequate power and it's only real disadvantage for targets is the very low bc of the pellets makes it more wind sensitive. But if you are hand pumping the low regulator setting makes it possible to fill to a lower pressure and the greater shot count keeps you shooting longer before refilling.