I'm not claiming my way to be superior than any other but here goes what i do now.
Either choose the projectile you want to use and tune to it, or shoot some different weights to see what the valve/hammer/spring can accommodate with the pressure you are presenting it via regulated or unregulated pressure. Depending on caliber, twist rate and air use that is acceptable too.
I re tuned my impact yesterday for the 100th change, so I tuned for more power than I wanted with the adjustments wide open(no change to my final regulator settings today) , then I start to reduce the adjustments to get consistent spread, tight groups, and a harmonious tune that just sounds like the gun is working smoothly. For the impact it's was spring tension and valve travel adjustments. For my dreamline it was just achieving 850-865 fps at 150 bar. For unregulated guns I tune for efficiency and find a pellet that is precise while efficient and stays sub 930 fps. It's a process, take notes. The notes have allowed me to go back do different tunes later.
This process allowed me to shoot 23 grain slugs really fast at my lowest power setting and 31 grain slugs at my desired speed and precision at max power with minimal mid range trajectory difference between them.
There's some known good projectiles to start with too. If 22, 18 jsb, h&n cudas, monster redesigns, hades, heavy hades. If 25 cal, jsb kings, or hades do not dissapoint. My favorite lately have been heavy hades in 22 since they blur the performance curve between pellet and slug
Best of luck on your adventure.