Accuracy IS always supreme. No matter the caliber, no matter the distance. It's up to the shooter to know his and his equipments limits. The question was about ethical kills. Your examples, while valid, only pertain to the 2% of idiots that would take those shots. A double lung shot is not anymore guaranteed with a .45 as with a .20. Too many variables come in to play at the squeeze of the trigger. It's seen with archery as deer duck the arrow and squirrels ducking the pellet at further distances. The longer the shot, the more time an animal has to react when it hears the sound before the projectile gets there. Suppressors do help with that, though. When you know the limits and stay within them, accuracy is ALWAYS supreme.