It happens to me. Not often but it does happen. I shootnothing but slugs out of mine. The first thing I notice is group sizes start to open up. Then shots start hitting low.
I think that pellets will not be affected in the same way. Probably just hit low as Emu said. Pellets are not as velocity sensitive as slugs? Speculating, not stating fact.
Over 1500 slugs, shot off reg at least 8 times with no dire consequences to date.