I would love to know why some barrels shoot a particular pellet well while others with equivalent design prefer a different pellet. I have two barrels for my P35-25. One shoots JSB heavies, 34 grain, best. The other prefers H&N Baracuda pellets. Same design, same manufacturer (SPA). If we cannot explain this sort of thing it seems unlikely we can explain preference for pellets and slugs versus just pellets.
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But we do know that slugs want a faster twist rate while pellets may shoot most accurately with a slower twist over 1 in 20. But most airguns seem to come with a twist rate around 1 in 18 which seems to be fast enough for slugs. My Caiman X has this sort of twist and will shoot both pellets and slugs accurately. But my P35s have about the same twist rate and I've only found a slug the 177 will shoot reasonably. Nothing I've tried in the 22 and 25 will group.
My guess is many guns are more picky about slugs making it harder to find a slug/gun match. If the twist is fast enough it may be a question of searching hard enough to find a slug your gun likes. But my Caiman doesn't seem to be picky. All H&Ns 21 to 30 grains will group about 1/2 inch at 30 yards. Not sure about others.
My Caiman X and P35s are choked.